NITRIC OXIDE (NO)
What if you could say NO to biofilm?
The treatment of biofilm infections is a difficult challenge that requires new solutions.
Stages
NO inactivates extracellular proteins, freely penetrates bacterial cell walls, and inactivates internal cell wall proteins
;
NO destroys (or damages) microbial DNA
;
NO inhibits DNA replication
;
NO inactivates iron-sulphur clusters essential in metabolism, respiration, etc.
;
Stages
NO breaks down biofilm EPS
;
NO causes biofilm dispersal
;
NO prevents communication in the biofilm
;
Antimicrobial action
- Increased permeability of microbial cells
- Replication inhibition
- Microbial processes disruption
Antimicrobial action
- Biofilm matrix breakdown
- Bacteria dispersal
- Impaired bacterial communication
Big losses can start from small misses
In a disease with many challenging variables to control, small misses can be devastating. Improving our understanding of diabetic foot ulcers will enhance prevention and management strategies for DFUs.
The invisible barrier to healing
One of the main reasons why wounds are so difficult to heal is related to the presence of biofilms, which affects all phases of wound healing and is considered an independent factor in delaying normal wound healing.
